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Literature summary extracted from

  • Rijal, S.; Fleming, S.; Cummings, N.; Rynkiewicz, N.K.; Ooms, L.M.; Nguyen, N.Y.; Teh, T.C.; Avery, S.; McManus, J.F.; Papenfuss, A.T.; McLean, C.; Guthridge, M.A.; Mitchell, C.A.; Wei, A.H.
    Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML (2015), Blood, 125, 2815-2824 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.66 medicine in acute myeloid leukemia, isoform IPNPP4B is significantly overexpressed, in association with reduced responses to chemotherapy, early relapse, and poor overall survival, independent of other risk factors. Ectopic overexpression of INPP4B confers leukemic resistance to cytosine arabinoside, daunorubicin, and etoposide. Expression of phosphatase inert variant C842A fails to abrogate resistance of acute myeloid leukemiacells to chemotherapy in vitro or in vivo. Targeted suppression of endogenously overexpressed INPP4B by RNAi sensitizes acute myeloid leukemia cell lines and primary acute myeloid leukemia to chemotherapy Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.66
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.66 C842A loss of catalytic activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.66 Homo sapiens O15327
-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.3.66 INPP4B
-
 Homo sapiens